SingleApproved OtherRegulatory LabelModerate confidenceSourced

Melanotan 1

An alpha-MSH analogue best anchored to afamelanotide evidence. The authorised medicine is a 16 mg controlled-release implant, not a reconstituted research vial.

Evidence context, not a personal protocol

Quantities below reproduce their stated source context—label, human study, laboratory work or educational guide. They do not assess suitability, product equivalence or individual risk.

Community-reported schedule

Community-reported · not a validated schedule

Community dose schedule

A community-provenance subcutaneous tanning titration for the reconstituted Melanotan 1 powder, distinct from the authorised afamelanotide implant. Community reports only, not a validated or trial-verified schedule.

Evidence source

Reported maximum quantity

Tanning titration (forum)

Choose the maximum quantity reported by this community line. Any earlier phase can be selected below for its arithmetic.

Reported quantities by phase

Select a point for its calculation examples

Low test (days 1-3)
50-100 mcg
Reports begin at 50-100 mcg to gauge nausea and titrate by skin response.
Tanning load (to day 10)
1 mg
titrate up
Dedicated tanning reports run about 1 mg a day for days 1-10; the range spans 200 mcg to 1.5 mg.
Maintenance (a few times weekly)
100 mcg
step down
Once colour is reached, reports drop to about 100 mcg a few times weekly.

Vial-aware arithmetic

Reconstitution examples, up to 3 mL

Choose the vial quantity and BAC water first. The diagram and results below update for the selected 50-100 mcg reported quantity. Higher-strength vials may naturally land outside the 20-30 unit band.

Vial quantity

Choose the quantity printed on the vial.

BAC water added

Use 1, 2 or 3 mL, or enter a custom volume up to 3 mL.

Open the full reverse calculator

Three millilitre research vial, diluent vial and capped U-100 syringe on an ink-blue surface — One small vial, one measured diluent volume and one U-100 scale. The arithmetic connects all three.

BAC water selected

3 mL

Basic example limit: 3 mL maximum. Check the actual vial and product-specific limits.

U-100 draw3 U

20-30 U reference band

1 mL BAC

1 units

resulting U-100 draw

Concentration: 10 mg/mL
BAC added: 1 mL

2 mL BAC

2 units

resulting U-100 draw

Concentration: 5 mg/mL
BAC added: 2 mL

3 mL BAC

3 units

resulting U-100 draw

Concentration: 3.333 mg/mL
BAC added: 3 mL

Shown in the diagram. Closest of these examples to 25 units.

Formula: draw units = selected mg × BAC mL ÷ vial mg × 100. The 20-30 unit band is a measurement reference, not a recommendation. Results are mathematical examples, not preparation instructions.

Dosage and protocol evidence

Each card states what the quantities are based on. A third-party or animal schedule is not a validated human dose.

Regulatory LabelControlled-release implantEvery 60 days

Adults with erythropoietic protoporphyria

A 16 mg subcutaneous controlled-release implant every 60 days

The pivotal trials and European product information concern a professionally inserted implant, not a reconstituted vial.

View source

Community GuideSubcutaneous in reportsDaily loading, then a few times weekly

authenticated research-forum (Peppys) Melanotan 1 powder-vial reports

Subcutaneous reports for the reconstituted powder begin around 50-100 mcg to gauge nausea and titrate by skin response; dedicated tanning runs cite roughly 1 mg a day for days 1-10 (some 200 mcg-1.5 mg), stepping down to about 100 mcg a few times weekly for maintenance, while general use settles near 100 mcg daily

Forum provenance from an authenticated archive with usernames omitted, describing a lyophilised product sold as Melanotan 1 and kept entirely separate from the authorised afamelanotide implant above. Reported quantities conflict, nausea and flushing are dose-limiting, one report describes an allergic reaction, and the archive does not establish a validated regimen.

View source

Evidence summary

An alpha-MSH analogue best anchored to afamelanotide evidence. The authorised medicine is a 16 mg controlled-release implant, not a reconstituted research vial.

Protocol basis

The strongest protocol is the authorised afamelanotide implant schedule for erythropoietic protoporphyria. It establishes a clinical formulation and interval but does not transfer to powder sold under the Melanotan 1 name.

What remains uncertain

Identity, release kinetics, sterility and exposure from a reconstituted vial are not established by the implant literature.

Community provenance (Peppys)

An authenticated research-forum archive records subcutaneous dosing of a reconstituted powder sold as Melanotan 1, kept entirely separate from the authorised afamelanotide implant. Reports describe beginning at 50-100 mcg to gauge nausea and titrating by skin response; dedicated tanning runs cite roughly 1 mg a day for the first ten days - with a spread from 200 mcg to about 1.5 mg - before dropping to around 100 mcg a few times weekly, while general use settles near 100 mcg daily. Nausea and post-injection flushing are the usual reasons quantities stay low, and one report describes an allergic reaction. Usernames and post numbers are omitted and the figures are logged as community provenance without endorsement; nothing here bridges to the authorised implant. The planner above reproduces the arithmetic of these reported quantities; it does not validate them.

Online research community archive check

Only passing Melanotan 1 references were found in the archive, with no powder-vial quantity, timing, loading or maintenance protocol. Nothing in the online research community material bridges the gap to the authorised afamelanotide implant.

Warnings and contraindications

The authorised afamelanotide product is a controlled-release implant administered by trained clinicians for a specific rare disease.

A lyophilised product sold as Melanotan 1 is not interchangeable with the authorised implant.

Skin pigmentation can obscure changes in moles; specialist skin monitoring is part of the authorised context.

Organised research bench with labelled storage tray, vial rack, notebook and thermometer — A clean workspace supports traceability. It does not establish sterility.

Shared across protocols

Supplies and general handling

Keep the universal checklist short. Product-specific labelling and source documentation always take priority over a general guide.

Research vial

Select the labelled vial quantity used in the calculation.

View Peppys vial

Bacteriostatic water

Use only a diluent appropriate to the research method and formulation.

View Peppys BAC water

U-100 measuring syringe

Use a new sterile device for every entry. Source locally.

Source locally

Wipes and sharps container

Plan clean handling and immediate sharps disposal. Source locally.

Source locally

Storage follows the label

Do not apply a universal refrigerator rule. Follow the product, diluent and study documentation for temperature, light and expiry.

Use sterile equipment once

CDC injection-safety guidance calls for a new sterile needle and syringe for each injection and entry into a medication container.

Stability is formulation-specific

Do not infer a post-mixing lifetime from BAC water alone. Discard material when identity, integrity or sterility is in doubt.

General references: CDC injection safety, NHS medicine storage and DailyMed BAC water labelling.